Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945872 | 0.89 | MAPT (0.52) | LMNAMAPTKDM4EHPGDPOLB | |
| SCHEMBL2092062 | 0.77 | LMNA (0.69) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL2092059 | 0.76 | LMNA (0.67) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL12883186 | 0.76 | TSHR (0.77) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL3952909 | 0.74 | ALDH1A1 (0.68) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL11578854 | 0.74 | LMNA (0.70) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL3899409 | 0.74 | LMNA (0.96) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL4214095 | 0.74 | LMNA (0.65) | LMNAMAPTHPGDPOLBMEN1 | |
| SCHEMBL13603822 | 0.74 | KDM4E (0.45) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL10333606 | 0.73 | POLB (0.64) | LMNAMAPTHPGDPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |