Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742566 | 0.89 | LMNA (0.57) | MAPTKDM4EKMT2AMEN1LMNA | |
| SCHEMBL6715760 | 0.84 | MEN1 (0.54) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL28707285 | 0.83 | MEN1 (0.61) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL30300553 | 0.78 | MEN1 (0.62) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL20226094 | 0.77 | MAPT (0.45) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL5838290 | 0.76 | MEN1 (0.61) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL9474708 | 0.75 | POLB (0.57) | MAPTKDM4EKMT2AMEN1CYP1A2 | |
| SCHEMBL6715757 | 0.74 | ALDH1A1 (0.54) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL1232491 | 0.73 | MAPT (0.58) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL28911206 | 0.72 | MEN1 (0.56) | MAPTKDM4EKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150190411-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-09 | — | — | US | disclosed |
| US-20100075926-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-25 | — | — | US | disclosed |
| US-20100075926-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-25 | — | — | US | disclosed |
| WO-2010011318-A2 | ACTIVATIQN OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075926-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | GRIK5, HDAC11, GRIK1 | MAPT 709/4885KDM4E 826/4885KMT2A 1179/4885 |
| US-20150190411-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | GRIK5, HDAC11, GRIK1 | MAPT 704/4885KDM4E 833/4885KMT2A 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.