Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ADH5 | P11766 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425680 | 0.80 | PDE3B (0.43) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7338886 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL10574724 | 0.78 | CYP3A4 (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL7341944 | 0.78 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL15759856 | 0.73 | CYP3A4 (0.63) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL608826 | 0.72 | ADH5 (0.67) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL611481 | 0.72 | CYP3A4 (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5307055 | 0.71 | MAOB (0.67) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL6324509 | 0.71 | MAPT (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7266072 | 0.71 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329070-B1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMA (US) | 1994-01-05 | — | — | EP | claimed |
| US-4866182-A | TREATMENT OF HEART FAILURE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-12 | — | — | US | claimed |
| EP-0329070-A1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-23 | — | — | EP | claimed |
| JP-2149571-A | — | — | None | — | — | JP | disclosed |
| EP-0329070-B1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMA (US) | 1994-01-05 | — | — | EP | disclosed |
| JP-H02149571-A | CARDIOTONIC ALKANOYL AND AROYL OXAZOLONE | MERRELL DOW PHARMACEUT INC | 1990-06-08 | — | — | JP | disclosed |
| US-4866182-A | TREATMENT OF HEART FAILURE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-12 | — | — | US | disclosed |
| EP-0329070-A1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-23 | — | — | EP | disclosed |