Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123693 | 0.80 | EZH2 (0.51) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| SCHEMBL7425711 | 0.74 | POLB (0.42) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| SCHEMBL3436319 | 0.73 | CCNC (0.49) | SIRT2SIRT1NPC1MAPTCA12 | |
| SCHEMBL8682160 | 0.73 | HSD17B10 (0.40) | SIRT2SIRT1NPC1MAPTCA12 | |
| Hydrochloric Acid SCHEMBL8683788 | 0.73 | ALDH1A1 (0.40) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| Hydrochloric Acid SCHEMBL8683796 | 0.73 | ALDH1A1 (0.40) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| SCHEMBL904672 | 0.72 | MAPT (0.48) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| SCHEMBL4959328 | 0.72 | MAOA (0.43) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| SCHEMBL7426706 | 0.71 | CHEK1 (0.56) | SIRT2SIRT1NPC1MAPTNLRP3 | |
| SCHEMBL7426302 | 0.70 | EGFR (0.45) | NPC1MAPTNLRP3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054871-A2 | PYRIMIDINES AND TRIAZINES AS INTEGRIN ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999050249-A2 | PYRIMIDINES AND TRIAZINES AS INTEGRIN ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-10-07 | — | — | WO | disclosed |