Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123693 | 0.85 | EZH2 (0.51) | HSD17B10ALDH1A1HPGDCA12CA1 | |
| Hydrochloric Acid SCHEMBL8683796 | 0.82 | ALDH1A1 (0.40) | ALDH1A1HPGDCA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL8683788 | 0.82 | ALDH1A1 (0.40) | ALDH1A1HPGDCA12CA1CA2 | |
| SCHEMBL8687401 | 0.77 | CYP1A2 (0.50) | HSD17B10HTTALDH1A1HPGDCA12 | |
| SCHEMBL3436319 | 0.76 | CCNC (0.49) | HSD17B10ALDH1A1CA12CA1CA2 | |
| SCHEMBL904672 | 0.74 | MAPT (0.48) | ALDH1A1HPGDCA12CA1CA2 | |
| SCHEMBL8682678 | 0.74 | ITGB3 (0.46) | HTTALDH1A1EZH2RAB9AMEN1 | |
| SCHEMBL7426706 | 0.73 | CHEK1 (0.56) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL7425720 | 0.73 | SIRT2 (0.39) | ALDH1A1HPGDCA12CA1CA2 | |
| SCHEMBL16595907 | 0.73 | EZH2 (0.49) | HSD17B10ALDH1A1HPGDEZH2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |