Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743157 | 1.00 | HRH1 (0.63) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL763158 | 0.80 | HRH1 (0.68) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL742584 | 0.78 | USP2 (0.53) | HRH1CHRM1USP2POLBKCNH2 | |
| SCHEMBL739842 | 0.77 | HRH1 (0.70) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL739843 | 0.77 | HRH1 (0.70) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL16760326 | 0.75 | TAAR1 (0.63) | HRH1CHRM1OPRM1OPRD1OPRK1 | |
| Piperidine SCHEMBL742276 | 0.75 | HRH1 (0.67) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL742781 | 0.73 | KCNH2 (0.48) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL18991211 | 0.72 | USP2 (0.56) | HRH1CHRM1USP2POLBOPRM1 | |
| SCHEMBL14447485 | 0.70 | JAK2 (0.47) | USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |