Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298439 | 1.00 | DPP4 (0.48) | DPP4SLC1A3SLC1A2SLC1A1LMNA | |
| Hydrochloric Acid SCHEMBL8538778 | 0.98 | DPP4 (0.46) | DPP4SLC1A3SLC1A2SLC1A1LMNA | |
| SCHEMBL8691399 | 0.85 | ANPEP (0.51) | MEN1KMT2A | |
| SCHEMBL6539850 | 0.85 | ESR1 (0.47) | LMNACYP2D6SRCPTGS1SLC7A5 | |
| SCHEMBL830226 | 0.84 | CYP2C9 (0.49) | LMNACYP2D6POLBMEN1KMT2A | |
| SCHEMBL22262278 | 0.84 | ALDH1A1 (0.48) | SLC1A3SLC1A2SLC1A1LMNAMEN1 | |
| SCHEMBL5006674 | 0.83 | CPN1 (0.53) | SLC1A3SLC1A2SLC1A1LMNA | |
| Hydrochloric Acid SCHEMBL6779703 | 0.81 | GRM8 (0.46) | LMNAKMT2APKM | |
| Hydrochloric Acid SCHEMBL6773597 | 0.81 | GRM8 (0.46) | LMNAKMT2APKM | |
| SCHEMBL687445 | 0.78 | LMNA (0.52) | LMNACYP2D6SRCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691953-B1 | 1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2000-08-02 | — | — | EP | disclosed |
| US-5721366-A | PHENYLAMIDINE DERIVATIVES | G. D. SEARLE & CO (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1994022820-A1 | 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-10-13 | — | — | WO | disclosed |