Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.59 |
| ▸ | CTSS | P25774 | 4/20 | 0.59 |
| ▸ | CTSK | P43235 | 4/20 | 0.59 |
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
| ▸ | GRN | P28799 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24283563 | 0.92 | CTSL (0.64) | CTSLCTSSCTSKGPR139TAS1R3 | |
| SCHEMBL24283565 | 0.92 | CTSL (0.64) | CTSLCTSSCTSKGPR139TAS1R3 | |
| SCHEMBL7429879 | 0.89 | CTSL (0.59) | CTSLCTSSCTSKGPR139TAS1R3 | |
| SCHEMBL7417805 | 0.83 | GRN (0.62) | CTSLCTSSCTSKGPR139GRN | |
| SCHEMBL5869846 | 0.81 | CTSL (0.53) | CTSLCTSSCTSKGPR139TAS1R3 | |
| SCHEMBL5869864 | 0.81 | CTSL (0.53) | CTSLCTSSCTSKGPR139TAS1R3 | |
| SCHEMBL5869856 | 0.81 | CTSL (0.53) | CTSLCTSSCTSKGPR139TAS1R3 | |
| SCHEMBL7427022 | 0.81 | PIN1 (0.56) | CTSKTAS1R3TAS1R1GRNSORT1 | |
| SCHEMBL6183715 | 0.81 | CTSL (0.76) | CTSLCTSSCTSKGPR139 | |
| SCHEMBL13753833 | 0.80 | TAS1R3 (0.63) | CTSLCTSSCTSKGPR139TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |