Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420200 | 0.87 | FAAH (0.48) | TP53MDM2MAPTRAB9A | |
| SCHEMBL7880879 | 0.84 | NCEH1 (0.48) | NCEH1TP53RAB9AMGLLNPC1 | |
| SCHEMBL7886936 | 0.83 | PTPN1 (0.48) | MAPT | |
| SCHEMBL7425279 | 0.82 | NCEH1 (0.46) | NCEH1MAPTRAB9ANPC1 | |
| SCHEMBL7886963 | 0.82 | NPC1 (0.47) | NCEH1MAPTRAB9ANPC1 | |
| SCHEMBL7890876 | 0.82 | ALDH1A1 (0.54) | — | |
| SCHEMBL7892983 | 0.81 | TSHR (0.50) | — | |
| SCHEMBL7890880 | 0.79 | ALDH1A1 (0.58) | — | |
| SCHEMBL8200539 | 0.77 | HSP90AA1 (0.55) | TP53MDM2MAPT | |
| SCHEMBL13342857 | 0.72 | SMN1; SMN2 (0.53) | NCEH1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0934301-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016521-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 1998-04-23 | — | — | WO | disclosed |