Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19194199 | 0.82 | TNKS2 (0.47) | HTR2AHTR2CHTR2BTNKS2SMN1; SMN2 | |
| SCHEMBL11392849 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BTSHRSMN1; SMN2 | |
| SCHEMBL13144363 | 0.80 | TSHR (0.53) | HTR2AHTR2CHTR2BTSHRSMN1; SMN2 | |
| SCHEMBL6565876 | 0.77 | TNKS2 (0.39) | HTR2AHTR2CHTR2BTNKS2TSHR | |
| SCHEMBL7496340 | 0.77 | HTR2A (0.53) | HTR2AHTR2CHTR2BTSHRSMN1; SMN2 | |
| SCHEMBL20970954 | 0.77 | HTR2A (0.79) | HTR2AHTR2CHTR2BTSHRSMN1; SMN2 | |
| SCHEMBL22609994 | 0.76 | TNKS2 (0.62) | HTR2AHTR2CHTR2BTNKS2TSHR | |
| SCHEMBL7155312 | 0.75 | TSHR (0.53) | HTR2AHTR2CHTR2BTSHRSMN1; SMN2 | |
| SCHEMBL8772645 | 0.74 | TNKS2 (0.54) | HTR2AHTR2CHTR2BTNKS2 | |
| SCHEMBL2007007 | 0.73 | TNKS2 (0.68) | HTR2AHTR2CHTR2BTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127049-A1 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL Holdings, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |