Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392849 | 0.89 | HTR2A (0.50) | HTR2AHTR2CHTR2BTSHRCALM1 | |
| SCHEMBL6775456 | 0.83 | TSHR (0.48) | HTR2AHTR2CHTR2BTSHRGAA | |
| SCHEMBL20970954 | 0.80 | HTR2A (0.79) | HTR2AHTR2CHTR2BTSHRCALM1 | |
| SCHEMBL5273093 | 0.79 | SMN1; SMN2 (0.39) | HTR2AHTR2CHTR2BSMN1; SMN2LMNA | |
| SCHEMBL6196869 | 0.79 | HTR2A (0.45) | HTR2AHTR2CHTR2BTSHRCALM1 | |
| SCHEMBL6196873 | 0.79 | HTR2A (0.45) | HTR2AHTR2CHTR2BTSHRCALM1 | |
| SCHEMBL7493068 | 0.78 | CALM1 (0.54) | TSHRCALM1GAASMN1; SMN2LMNA | |
| SCHEMBL5267095 | 0.78 | THRA (0.42) | HTR2AHTR2CHTR2BSMN1; SMN2KMT2A | |
| SCHEMBL7426586 | 0.77 | HTR2A (0.50) | HTR2AHTR2CHTR2BTSHRCALM1 | |
| SCHEMBL7954477 | 0.77 | TSHR (0.43) | HTR2AHTR2CHTR2BTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638075-B1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| CN-1067992-C | Substituted thiazolidine derivatives and pharmaceutical compositions containing them and use thereof | OTSUKA PHARMA CO LTD (JP) | 2001-07-04 | — | — | CN | disclosed |
| CN-1184105-A | Substituted thiazolidine derivatives and pharmaceutical compositions containing them and use thereof | OTSUKA PHARMA CO LTD (JP) | 1998-06-10 | — | — | CN | disclosed |
| CN-1037842-C | Substituted thiazolidine derivatives, pharmaceutical compositions and uses thereof | OTSUKA PHARMA CO LTD (JP) | 1998-03-25 | — | — | CN | disclosed |
| US-5677322-A | THERAPY FOR AGING, DIABETES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| CN-1106982-A | Maillard reaction inhibitor | OTSUKA PHARMA CO LTD (JP) | 1995-08-16 | — | — | CN | disclosed |
| EP-0638075-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994019335-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |