SCHEMBL7426602

SCHEMBL7426602

O=C(O)c1cccc2c1SCCC2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
ALOX15 P16050 1/20 0.40
HTR1A P08908 1/20 0.39
ADRA2A P08913 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
CXCR5 P32302 2/20 0.38
GFER P55789 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
BCL2L1 Q07817 1/20 0.36
BAD Q92934 1/20 0.36
TSHR P16473 1/20 0.36
NR4A1 P22736 1/20 0.36
NR4A2 P43354 1/20 0.36
NR4A3 Q92570 1/20 0.36
MCL1 Q07820 1/20 0.36
RXRA P19793 4/20 0.35
RXRB P28702 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7325790 0.89 ALDH1A1 (0.43) ALDH1A1ALOX15TSHRNR4A1NR4A2
SCHEMBL7417670 0.85 HTR1A (0.34) ALDH1A1HTR1AADRA2ASLC6A2SLC6A4
SCHEMBL7526110 0.76 BCL2L1 (0.48) ALDH1A1ALOX15HTR1AADRA2ASLC6A2
SCHEMBL3613341 0.73 CXCR5 (0.53) ALDH1A1ALOX15CXCR5GFERMEN1
SCHEMBL29493191 0.73 CXCR5 (0.56) ALDH1A1ALOX15CXCR5GFERMEN1
SCHEMBL783869 0.73 CXCR5 (0.56) ALDH1A1ALOX15CXCR5GFERMEN1
SCHEMBL28195045 0.73 PARP1 (0.50) ALDH1A1ALOX15TSHRKDM4EHPGD
Phthalic Acid SCHEMBL27608269 0.72 ALDH1A1 (0.64) ALDH1A1ALOX15CXCR5MEN1KMT2A
SCHEMBL7425526 0.72 AKR1C3 (0.41) ALDH1A1MEN1KMT2ATSHRNR4A1
SCHEMBL7325775 0.72 ALDH1A1 (0.41) ALDH1A1ALOX15L3MBTL1TSHRNR4A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127379-A TREATING IRRITABLE BOWEL SYNDROME, URINARY INCONTINENCE, ATRIAL ARRHYTHMIA OR STROKE SMITHKLINE BEECHAM P.L.C. (GB) 2000-10-03 US disclosed
US-5968954-A EXHIBIT SELECTIVE BINDING AFFINITY FOR 5-HYDROXYTRYPTAMINE RECEPTORS ADIR ET COMPAGNIE (FR) 1999-10-19 US disclosed
EP-0625149-A1 BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-11-23 EP disclosed
WO-1993016072-A1 BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-08-19 WO disclosed