Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427677 | 1.00 | MAPT (0.48) | MAPTKDM4ERAB9ANPC1HPGD | |
| SCHEMBL9157538 | 0.88 | MAPT (0.52) | MAPTKDM4ERAB9ANPC1HPGD | |
| SCHEMBL9157528 | 0.88 | MAPT (0.52) | MAPTKDM4ERAB9ANPC1HPGD | |
| SCHEMBL11121684 | 0.76 | MAPT (0.56) | MAPTKDM4ERAB9ANPC1FKBP1A | |
| SCHEMBL10479627 | 0.75 | MAPT (0.57) | MAPTKDM4ERAB9ANPC1FKBP1A | |
| SCHEMBL6227110 | 0.74 | RAB9A (0.57) | MAPTKDM4ERAB9ANPC1FKBP1A | |
| SCHEMBL4719668 | 0.74 | MGLL (0.68) | MAPTKDM4ERAB9ANPC1FKBP1A | |
| SCHEMBL11321646 | 0.74 | MAPT (0.56) | MAPTKDM4ERAB9ANPC1FKBP1A | |
| SCHEMBL22501227 | 0.72 | MAPT (0.51) | MAPTKDM4ERAB9ANPC1FKBP1A | |
| SCHEMBL20886938 | 0.71 | KMT2A (0.64) | MAPTKDM4ERAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | claimed |
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |