Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739287 | 0.87 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1MAPTUSP30 | |
| SCHEMBL742853 | 0.87 | STS (0.47) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL17913759 | 0.81 | LMNA (0.62) | MEN1KMT2AALDH1A1LMNAGAA | |
| SCHEMBL740947 | 0.78 | MEN1 (0.47) | MEN1KMT2AALDH1A1MAPTUSP30 | |
| SCHEMBL6712179 | 0.78 | USP30 (0.49) | MEN1KMT2AALDH1A1MAPTUSP30 | |
| SCHEMBL21359263 | 0.77 | BCL9 (0.60) | MEN1KMT2AALDH1A1LMNAUSP30 | |
| SCHEMBL9995010 | 0.77 | GPR119 (0.47) | MEN1KMT2AUSP30STS | |
| SCHEMBL3739373 | 0.76 | USP30 (0.50) | MEN1KMT2AALDH1A1MAPTUSP30 | |
| SCHEMBL9994852 | 0.76 | STS (0.47) | MEN1KMT2AMAPTUSP30STS | |
| SCHEMBL3177877 | 0.76 | MEN1 (0.55) | MEN1KMT2AALDH1A1USP30ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |