Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465584 | 0.90 | PPARG (0.41) | PPARGTP53ROCK2TDP1POLB | |
| SCHEMBL7427533 | 0.89 | ALOX5AP (0.46) | PPARGTP53ALOX5APRXFP1PTGES | |
| SCHEMBL7425401 | 0.89 | MAPT (0.43) | PPARGTP53TDP1ALOX5APS1PR3 | |
| SCHEMBL29611861 | 0.89 | ALOX5AP (0.47) | PPARGTP53ALOX5APRXFP1 | |
| SCHEMBL687131 | 0.89 | ALOX5AP (0.47) | PPARGTP53ALOX5APRXFP1 | |
| SCHEMBL7707842 | 0.89 | ALOX5AP (0.45) | PPARGTP53ALOX5APRXFP1PTGES | |
| SCHEMBL7417850 | 0.84 | L3MBTL1 (0.40) | TDP1ALOX5APS1PR3EGLN3PTGES | |
| SCHEMBL3842264 | 0.84 | CNR2 (0.47) | ALOX5AP | |
| Hydrochloric Acid SCHEMBL7477963 | 0.83 | L3MBTL1 (0.39) | TDP1ALOX5APS1PR3EGLN3PTGES | |
| SCHEMBL7471782 | 0.83 | PTGES (0.46) | PPARGTP53RXFP1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |