Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427942 | 0.92 | PTGES (0.43) | PTGESTNFMAPTALDH1A1HPGD | |
| SCHEMBL7423725 | 0.88 | PTGES (0.40) | PTGESTNFMAPTALDH1A1HPGD | |
| SCHEMBL7421254 | 0.88 | PTGES (0.41) | PTGESTNFMAPTALDH1A1HPGD | |
| SCHEMBL7417850 | 0.84 | L3MBTL1 (0.40) | PTGESTNFMAPTALDH1A1KDM4E | |
| SCHEMBL3842264 | 0.84 | CNR2 (0.47) | TNFMAPTALDH1A1KDM4ENOD2 | |
| SCHEMBL7427533 | 0.83 | ALOX5AP (0.46) | PTGESALDH1A1RXFP1TP53L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7477963 | 0.83 | L3MBTL1 (0.39) | PTGESTNFMAPTALDH1A1KDM4E | |
| SCHEMBL7425401 | 0.83 | MAPT (0.43) | MAPTALDH1A1HPGDTP53KDM4E | |
| SCHEMBL7428111 | 0.83 | HDAC8 (0.44) | PTGESRXFP1TP53PPARG | |
| SCHEMBL7707842 | 0.83 | ALOX5AP (0.45) | PTGESALDH1A1RXFP1TP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |