Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22587326 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL7434346 | 0.85 | LMNA (0.42) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL8803612 | 0.82 | ALDH1A1 (0.57) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL22587266 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL22587345 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL22587265 | 0.75 | ALDH1A1 (0.51) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL22587267 | 0.75 | MAPK1 (0.52) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL22587354 | 0.73 | KDM4E (0.67) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL6119782 | 0.73 | KMT2A (0.54) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL20778195 | 0.72 | MAPK1 (0.63) | ALDH1A1MEN1GAAKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |