Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428453 | 0.85 | ALDH1A1 (0.52) | LMNASMN1; SMN2ALDH1A1MEN1GAA | |
| SCHEMBL22587313 | 0.84 | TP53 (0.47) | LMNAPARP1PARP2ALDH1A1MEN1 | |
| SCHEMBL22587339 | 0.79 | KDM4E (0.49) | SMN1; SMN2PARP1PARP2ALDH1A1MEN1 | |
| SCHEMBL22587286 | 0.76 | KMT2A (0.59) | PARP1PARP2ALDH1A1MEN1GAA | |
| SCHEMBL22587273 | 0.74 | CYP2C9 (0.58) | LMNAALDH1A1KDM4EHSD17B10NPSR1 | |
| SCHEMBL22599063 | 0.74 | PKM (0.44) | LMNASMN1; SMN2PARP1PARP2ALDH1A1 | |
| SCHEMBL22598628 | 0.74 | HSD17B10 (0.41) | LMNAPARP1PARP2ALDH1A1MEN1 | |
| SCHEMBL18294954 | 0.73 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2CCNE1CDK2ALDH1A1 | |
| SCHEMBL22587312 | 0.71 | KDM4E (0.40) | LMNAPARP1PARP2ALDH1A1MEN1 | |
| SCHEMBL22587326 | 0.71 | ALDH1A1 (0.55) | LMNAALDH1A1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |