Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421260 | 0.91 | S1PR3 (0.40) | TP53MAPTS1PR3SMN1; SMN2P2RX7 | |
| SCHEMBL7425218 | 0.90 | MEN1 (0.42) | TP53MAPTRXFP1POLBSMN1; SMN2 | |
| SCHEMBL7418596 | 0.89 | MAPT (0.38) | TP53MAPTS1PR3 | |
| SCHEMBL7420228 | 0.89 | MAPT (0.38) | TP53MAPTS1PR3SMN1; SMN2 | |
| SCHEMBL7472730 | 0.89 | MEN1 (0.39) | TP53MAPTRXFP1SMN1; SMN2P2RX7 | |
| SCHEMBL7425401 | 0.88 | MAPT (0.43) | TP53MAPTS1PR3 | |
| SCHEMBL7707832 | 0.85 | S1PR3 (0.44) | MAPTS1PR3 | |
| SCHEMBL7466262 | 0.84 | S1PR3 (0.41) | MAPTS1PR3POLBSMN1; SMN2 | |
| SCHEMBL7416292 | 0.84 | S1PR3 (0.46) | TP53MAPTS1PR3 | |
| SCHEMBL7425649 | 0.84 | MAPT (0.47) | MAPTS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |