Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472730 | 0.92 | MEN1 (0.39) | MEN1KMT2ASMN1; SMN2TP53MAPT | |
| SCHEMBL7418814 | 0.90 | OXER1 (0.41) | MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7428559 | 0.90 | TP53 (0.50) | SMN1; SMN2TP53MAPTPOLBRXFP1 | |
| SCHEMBL7425988 | 0.89 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7427469 | 0.89 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL7707845 | 0.89 | SLC22A12 (0.37) | AGTR1AGTR2 | |
| SCHEMBL7427533 | 0.87 | ALOX5AP (0.46) | MEN1KMT2ATP53RXFP1 | |
| SCHEMBL7707842 | 0.87 | ALOX5AP (0.45) | MEN1KMT2ATP53RXFP1 | |
| SCHEMBL8021059 | 0.85 | MAPT (0.43) | MEN1KMT2ASMN1; SMN2TP53MAPT | |
| SCHEMBL7425450 | 0.83 | AGTR1 (0.46) | MEN1KMT2ATP53MAPTAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |