Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421260 | 0.91 | S1PR3 (0.40) | MAPTTP53S1PR3USP14PPARG | |
| SCHEMBL7425988 | 0.90 | AGTR1 (0.36) | ALOX5APALDH1A1PLA2G2A | |
| SCHEMBL7420228 | 0.89 | MAPT (0.38) | MAPTTP53S1PR3USP14PPARG | |
| SCHEMBL7428559 | 0.89 | TP53 (0.50) | MAPTTP53S1PR3 | |
| SCHEMBL7420996 | 0.89 | LMNA (0.40) | MAPTTP53ALOX5APPPARGALDH1A1 | |
| SCHEMBL7425401 | 0.88 | MAPT (0.43) | MAPTTP53S1PR3ALOX5APPPARG | |
| SCHEMBL7425567 | 0.87 | ALOX5AP (0.36) | ALOX5APPPARGDPP4PLA2G2A | |
| SCHEMBL7472730 | 0.87 | MEN1 (0.39) | MAPTTP53ALOX5AP | |
| SCHEMBL29611861 | 0.86 | ALOX5AP (0.47) | TP53ALOX5APPPARGALDH1A1CYP1A2 | |
| SCHEMBL687131 | 0.86 | ALOX5AP (0.47) | TP53ALOX5APPPARGALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |