Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644988 | 0.87 | PNMT (0.43) | ENPP2PNMTNPC1RAB9APOLB | |
| SCHEMBL8472728 | 0.85 | PNMT (0.44) | ENPP2PNMTNPC1RAB9APOLB | |
| SCHEMBL6502789 | 0.81 | PNMT (0.54) | ENPP2PNMTNPC1RAB9AMAOA | |
| SCHEMBL8541013 | 0.80 | ENPP2 (0.47) | ENPP2NR1H4PNMTNPC1RAB9A | |
| SCHEMBL31633620 | 0.80 | PNMT (0.53) | ENPP2PNMTNPC1RAB9AMAOA | |
| SCHEMBL29430517 | 0.79 | PNMT (0.47) | ENPP2PNMTNPC1RAB9AALDH1A1 | |
| SCHEMBL3459355 | 0.79 | PNMT (0.47) | ENPP2PNMTNPC1RAB9AALDH1A1 | |
| SCHEMBL29222741 | 0.79 | NPC1 (0.48) | PNMTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL27703872 | 0.79 | PNMT (0.51) | ENPP2PNMTNPC1RAB9AMAOA | |
| Water SCHEMBL15362024 | 0.78 | PNMT (0.46) | ENPP2PNMTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000061631-A1 | MODIFIED PENTAPEPTIDE ANTAGONISTS OF THE ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |