Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.55 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7428842 | 0.98 | HSD11B1 (0.54) | HSD11B1PSIP1CA12CA9KMT2A | |
| Hydrochloric Acid SCHEMBL27584144 | 0.86 | HSD11B1 (0.55) | HSD11B1PSIP1CA12CA9KMT2A | |
| SCHEMBL2024141 | 0.81 | KMT2A (0.73) | HSD11B1PSIP1CA12CA9KMT2A | |
| SCHEMBL13299613 | 0.79 | HSD11B1 (0.55) | HSD11B1PSIP1CA12CA9KMT2A | |
| SCHEMBL6751981 | 0.79 | KMT2A (0.71) | HSD11B1PSIP1CA12CA9KMT2A | |
| SCHEMBL27780458 | 0.77 | HSD11B1 (0.65) | HSD11B1PSIP1KMT2APOLBALDH1A1 | |
| SCHEMBL5080063 | 0.76 | HSD11B1 (0.58) | HSD11B1PSIP1CA12CA9KMT2A | |
| SCHEMBL4731443 | 0.76 | HSD11B1 (0.63) | HSD11B1PSIP1CA12CA9KMT2A | |
| SCHEMBL12750892 | 0.74 | KMT2A (0.58) | HSD11B1CA12CA9KMT2AALDH1A1 | |
| SCHEMBL27584145 | 0.73 | ALDH1A1 (0.55) | HSD11B1PSIP1CA12CA9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1379777-A | Amino-triazolopyridine derivatives | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |