Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592566 | 0.82 | CTSK (0.36) | KMT2AMEN1CTSLCTSSCTSK | |
| SCHEMBL7426104 | 0.77 | CTSK (0.55) | CTSLCTSSCTSK | |
| SCHEMBL7533634 | 0.72 | CTSK (0.42) | CCR2KMT2AADRB2CTSLCTSS | |
| SCHEMBL7538681 | 0.69 | ATM (0.49) | KMT2AKDM4EADRB2LMNAHTT | |
| SCHEMBL4772275 | 0.66 | MTNR1A (0.40) | KMT2AMEN1CYP2C19SMN1; SMN2L3MBTL1 | |
| SCHEMBL6213090 | 0.66 | CTSK (0.37) | CTSLCTSSCTSK | |
| SCHEMBL7428439 | 0.66 | MEN1 (0.48) | KMT2AMEN1KDM4EPOLBCYP2C19 | |
| SCHEMBL7429565 | 0.65 | CTSK (0.55) | CTSLCTSSCTSK | |
| SCHEMBL6401947 | 0.65 | PLA2G1B (0.46) | KMT2AMEN1CTSKLMNAHTT | |
| SCHEMBL4686330 | 0.65 | CTSK (0.60) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |