Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.35 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426883 | 0.78 | PAX8 (0.43) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7480516 | 0.69 | CTSK (0.41) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7431356 | 0.67 | KMT2A (0.46) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7434831 | 0.66 | KMT2A (0.48) | CYP3A4CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL7427486 | 0.66 | MEN1 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7429042 | 0.66 | HTR1A (0.38) | SMN1; SMN2CYP2C19MEN1KMT2AL3MBTL1 | |
| SCHEMBL7432035 | 0.66 | ALDH1A1 (0.48) | MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL7477927 | 0.66 | CTSK (0.50) | SMN1; SMN2 | |
| SCHEMBL7427121 | 0.65 | MEN1 (0.55) | SMN1; SMN2CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL7599077 | 0.64 | HCRTR1 (0.40) | RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |