Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | C1S | P09871 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.38 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.38 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437048 | 0.83 | ATP4A (0.51) | HDAC6C1SIDO1MAPTMEN1 | |
| SCHEMBL7435899 | 0.81 | MAPT (0.57) | HDAC3HDAC8HDAC6IDO1MAPT | |
| SCHEMBL7444028 | 0.81 | NR1H4 (0.44) | HDAC3HDAC8HDAC6MAPTMEN1 | |
| SCHEMBL7429806 | 0.80 | KDM4E (0.56) | CFTRHDAC6IDO1MAPTMEN1 | |
| SCHEMBL7437716 | 0.80 | ABL1 (0.52) | CFTRMAPTMEN1KMT2ARAB9A | |
| SCHEMBL7434052 | 0.79 | CYP3A4 (0.52) | CFTRHDAC3HDAC8HDAC6C1S | |
| SCHEMBL7441613 | 0.79 | MAPT (0.50) | HDAC3HDAC8HDAC6PLAUMAPT | |
| SCHEMBL7429092 | 0.77 | CFTR (0.47) | CFTRC1SPLGPLATPRSS1 | |
| SCHEMBL7426082 | 0.77 | MEN1 (0.51) | CFTRHDAC6IDO1MAPTMEN1 | |
| SCHEMBL7431073 | 0.76 | CSNK2A1 (0.57) | HDAC3HDAC8HDAC6MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |