Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HK1 | P19367 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.50 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.50 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444028 | 0.86 | NR1H4 (0.44) | MAPTALDH1A1RAB9AHPGDHK1 | |
| SCHEMBL7437716 | 0.84 | ABL1 (0.52) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL7429806 | 0.84 | KDM4E (0.56) | MAPTALDH1A1RAB9AHPGDHK1 | |
| SCHEMBL7437048 | 0.84 | ATP4A (0.51) | MAPTALDH1A1RAB9AHPGDHK1 | |
| SCHEMBL7441613 | 0.83 | MAPT (0.50) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL7438464 | 0.82 | MAPT (0.54) | MAPTALDH1A1RAB9AHPGDMEN1 | |
| SCHEMBL7426082 | 0.81 | MEN1 (0.51) | MAPTALDH1A1MEN1KMT2AHDAC6 | |
| SCHEMBL7429088 | 0.81 | CFTR (0.47) | MAPTALDH1A1RAB9AHPGDHK1 | |
| SCHEMBL7431073 | 0.80 | CSNK2A1 (0.57) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL7428965 | 0.80 | RAB9A (0.55) | MAPTALDH1A1RAB9AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |