Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 8/20 | 0.47 |
| ▸ | ATP4A | P20648 | 7/20 | 0.42 |
| ▸ | ATP4B | P51164 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434052 | 0.84 | CYP3A4 (0.52) | CFTRATP4AATP4BPLGPLAU | |
| SCHEMBL7437056 | 0.83 | ATP4A (0.61) | ATP4AATP4BALDH1A1LMNAMAPT | |
| SCHEMBL7444038 | 0.81 | ALDH1A1 (0.51) | ATP4AATP4BALDH1A1LMNAMAPT | |
| SCHEMBL7429814 | 0.80 | KDM4E (0.60) | ATP4AATP4BALDH1A1LMNAMAPT | |
| SCHEMBL7437724 | 0.80 | ATP4A (0.61) | CFTRATP4AATP4BALDH1A1LMNA | |
| SCHEMBL7435903 | 0.80 | ALDH1A1 (0.60) | ATP4AATP4BALDH1A1LMNAMAPT | |
| SCHEMBL7441627 | 0.79 | ALDH1A1 (0.61) | ATP4AATP4BALDH1A1LMNAMAPT | |
| SCHEMBL7426086 | 0.77 | ALDH1A1 (0.51) | CFTRALDH1A1MAPT | |
| SCHEMBL7429088 | 0.77 | CFTR (0.47) | CFTRALDH1A1MAPTPLGPLAU | |
| SCHEMBL7436562 | 0.76 | PTGS2 (0.45) | ATP4AATP4BALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |