Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30340281 | 1.00 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2MAPTSRC | |
| SCHEMBL16339494 | 0.89 | CYP11B1 (0.57) | CYP19A1CYP11B1CYP11B2MAPTSRC | |
| SCHEMBL21468447 | 0.87 | CYP11B1 (0.44) | CYP19A1CYP11B1CYP11B2MAPTPDE4B | |
| SCHEMBL6136841 | 0.87 | HTR2A (0.47) | CYP19A1CYP11B1CYP11B2MAPTPDE4B | |
| SCHEMBL13178659 | 0.86 | POLB (0.50) | CYP19A1CYP11B1CYP11B2MAPTPDE4B | |
| SCHEMBL6605984 | 0.85 | ALDH1A1 (0.45) | CYP19A1CYP11B1CYP11B2MAPTTP53 | |
| SCHEMBL3041636 | 0.83 | MAOA (0.53) | CYP19A1CYP11B1CYP11B2PDE4BKMT2A | |
| SCHEMBL12481477 | 0.82 | CHEK1 (0.42) | CYP19A1CYP11B1CYP11B2MAPTTP53 | |
| SCHEMBL578508 | 0.80 | SRC (0.57) | MAPTSRCEGFRTP53CYP3A4 | |
| SCHEMBL16339815 | 0.80 | CYP11B1 (0.49) | CYP19A1CYP11B1CYP11B2SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113372273-A | Ivabradine intermediate compound IV | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-113372274-B | Preparation method of ivabradine | 鲁南制药集团股份有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-113372274-B | Preparation method of ivabradine | 鲁南制药集团股份有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-113372274-A | Preparation method of ivabradine | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-113372273-A | Ivabradine intermediate compound IV | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-113372273-A | Ivabradine intermediate compound IV | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-113372274-A | Preparation method of ivabradine | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| US-4575503-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1986-03-11 | — | — | US | disclosed |
| US-4473575-A | ANGIOTENSIN INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| US-4410520-A | ANGIOTENSION CONVERTING ENZYME INGIBITOR, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0072352-A1 | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use | CIBA-GEIGY AG (CH) | 1983-02-16 | — | — | EP | disclosed |