Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443078 | 0.89 | DPP4 (0.40) | DPP4ADRA2AADRA2BADRA2CKCNN3 | |
| SCHEMBL7441954 | 0.83 | DPP4 (0.42) | DPP4UBE2MDCUN1D1TSHRKCNN3 | |
| SCHEMBL7443212 | 0.82 | DPP4 (0.41) | DPP4UBE2MDCUN1D1TSHRKCNN3 | |
| SCHEMBL7445707 | 0.81 | DPP4 (0.42) | DPP4UBE2MDCUN1D1TSHRKCNN3 | |
| SCHEMBL7429149 | 0.80 | KCNN3 (0.44) | DPP4KCNN3 | |
| SCHEMBL7436891 | 0.78 | DPP4 (0.40) | DPP4UBE2MDCUN1D1TSHR | |
| SCHEMBL7438702 | 0.75 | DPP4 (0.42) | DPP4UBE2MDCUN1D1TSHR | |
| SCHEMBL7441912 | 0.73 | DPP4 (0.41) | DPP4KCNN3 | |
| SCHEMBL7440552 | 0.73 | KCNN3 (0.38) | KCNN3 | |
| SCHEMBL7443099 | 0.72 | AGTR1 (0.47) | DPP4KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |