Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 9/20 | 0.44 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.44 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | GPR39 | O43194 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443099 | 0.90 | AGTR1 (0.47) | KCNN3KCNN1KCNN2F2PRSS1 | |
| SCHEMBL7441964 | 0.85 | KCNN3 (0.47) | KCNN3KCNN1KCNN2GAAMEN1 | |
| SCHEMBL7443235 | 0.83 | KCNN3 (0.44) | KCNN3KCNN1KCNN2GAAMEN1 | |
| SCHEMBL7445717 | 0.83 | KCNN3 (0.48) | KCNN3KCNN1KCNN2GAAMEN1 | |
| SCHEMBL7429133 | 0.80 | DPP4 (0.41) | KCNN3DPP4 | |
| SCHEMBL7440552 | 0.79 | KCNN3 (0.38) | KCNN3KCNN1KCNN2F2PRSS1 | |
| SCHEMBL7436916 | 0.78 | KCNN3 (0.44) | KCNN3KCNN1KCNN2GAAMEN1 | |
| SCHEMBL7441925 | 0.77 | AGTR1 (0.49) | KCNN3KCNN1KCNN2MAPKAPK2AGTR1 | |
| SCHEMBL7438720 | 0.75 | KCNN3 (0.47) | KCNN3KCNN1KCNN2GAAMEN1 | |
| SCHEMBL7442297 | 0.75 | AGTR1 (0.47) | KCNN3KCNN1KCNN2MAPKAPK2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |