Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16698148 | 0.86 | MYC (0.44) | ALDH1A1HPGDMYCCA1CA2 | |
| SCHEMBL247778 | 0.84 | ALDH1A1 (0.54) | ALDH1A1HPGDMYCCA1CA2 | |
| Bromide SCHEMBL27753498 | 0.82 | ALDH1A1 (0.52) | ALDH1A1HPGDMYCCA1CA2 | |
| SCHEMBL28218238 | 0.81 | THRB (0.46) | ALDH1A1HPGDMYCPLA2G7L3MBTL1 | |
| SCHEMBL6679648 | 0.81 | MYC (0.55) | ALDH1A1HPGDMYCCA1CA2 | |
| SCHEMBL6677410 | 0.79 | MYC (0.48) | HPGDMYCCA1CA2CA7 | |
| SCHEMBL7429889 | 0.79 | MYC (0.48) | ALDH1A1HPGDMYCPLA2G7L3MBTL1 | |
| SCHEMBL7430270 | 0.79 | MYC (0.49) | ALDH1A1HPGDMYCPLA2G7L3MBTL1 | |
| SCHEMBL9712532 | 0.78 | MYC (0.47) | ALDH1A1HPGDMYCCA1CA2 | |
| Bicarbonate SCHEMBL8972762 | 0.77 | MYC (0.54) | ALDH1A1HPGDMYCPLA2G7MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |