Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957159 | 0.87 | DRD2 (0.46) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL3035136 | 0.83 | DRD2 (0.37) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL3039847 | 0.83 | DRD2 (0.37) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL5954233 | 0.83 | DRD2 (0.37) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL7397490 | 0.82 | HTR1A (0.42) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL7397493 | 0.82 | HTR1A (0.42) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL7395323 | 0.81 | DRD2 (0.45) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL7395078 | 0.81 | DRD2 (0.41) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL7397482 | 0.81 | DRD2 (0.44) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL7395079 | 0.81 | DRD2 (0.41) | DRD2DRD4DRD3SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |