Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397493 | 1.00 | HTR1A (0.42) | HTR1AMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5957117 | 0.88 | HTR1A (0.52) | HTR1AMAPTLMNAMEN1KMT2A | |
| SCHEMBL5957060 | 0.83 | MAPT (0.51) | HTR1AMAPTDRD2SLC6A4DRD4 | |
| SCHEMBL3035136 | 0.82 | DRD2 (0.37) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3039847 | 0.82 | DRD2 (0.37) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7429388 | 0.82 | DRD2 (0.38) | HTR1AMAPTLMNAALDH1A1DRD2 | |
| SCHEMBL5954233 | 0.82 | DRD2 (0.37) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7395079 | 0.80 | DRD2 (0.41) | LMNAALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL7395078 | 0.80 | DRD2 (0.41) | LMNAALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL7395323 | 0.79 | DRD2 (0.45) | MAPTLMNAMEN1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |