Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | WNT1 | P04628 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704442 | 0.96 | SMN1; SMN2 (0.71) | SMN1; SMN2CYP1A2YTHDC1FLT3CDK2 | |
| SCHEMBL8714399 | 0.82 | HTT (0.74) | SMN1; SMN2CYP1A2YTHDC1FLT3CDK2 | |
| SCHEMBL31571485 | 0.81 | KDM4E (0.58) | SMN1; SMN2CYP1A2YTHDC1FLT3CDK2 | |
| SCHEMBL18851945 | 0.81 | YTHDC1 (0.61) | SMN1; SMN2CYP1A2YTHDC1FLT3CDK2 | |
| SCHEMBL31445444 | 0.80 | YTHDC1 (0.59) | SMN1; SMN2YTHDC1FLT3CDK2CCNA2 | |
| SCHEMBL19884728 | 0.80 | YTHDC1 (0.59) | SMN1; SMN2CYP1A2YTHDC1FLT3CDK2 | |
| SCHEMBL30036108 | 0.79 | YTHDC1 (1.00) | SMN1; SMN2YTHDC1FLT3CDK2CCNA2 | |
| SCHEMBL2723267 | 0.79 | YTHDC1 (1.00) | SMN1; SMN2YTHDC1FLT3CDK2CCNA2 | |
| SCHEMBL30398090 | 0.76 | FLT3 (1.00) | SMN1; SMN2YTHDC1FLT3CDK2CCNA2 | |
| SCHEMBL951125 | 0.76 | FLT3 (1.00) | SMN1; SMN2YTHDC1FLT3CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999017772-A1 | 5HT4 AGONISTS AND ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |