Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.47 |
| ▸ | METAP2 | P50579 | 6/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.36 |
| ▸ | METAP1 | P53582 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436027 | 0.82 | REN (0.52) | RENMETAP2CPB2METAP1 | |
| SCHEMBL9728015 | 0.81 | REN (0.44) | RENMETAP2CPB2METAP1 | |
| SCHEMBL9728012 | 0.81 | REN (0.44) | RENMETAP2CPB2METAP1 | |
| SCHEMBL7433023 | 0.79 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9260290 | 0.77 | REN (0.50) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9727591 | 0.74 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9727598 | 0.74 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9177605 | 0.73 | REN (0.53) | RENMETAP2CPB2METAP1 | |
| SCHEMBL7291539 | 0.73 | REN (0.53) | RENMETAP2CPB2METAP1 | |
| SCHEMBL10433749 | 0.73 | REN (0.53) | RENMETAP2CPB2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391179-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |