Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.47 |
| ▸ | METAP2 | P50579 | 7/20 | 0.38 |
| ▸ | METAP1 | P53582 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727591 | 1.00 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9728012 | 0.85 | REN (0.44) | RENMETAP2METAP1 | |
| SCHEMBL9728015 | 0.85 | REN (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7436027 | 0.79 | REN (0.52) | RENMETAP2METAP1 | |
| SCHEMBL7433023 | 0.79 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7432793 | 0.77 | METAP2 (0.48) | RENMETAP2METAP1 | |
| SCHEMBL9260290 | 0.77 | REN (0.50) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7429913 | 0.74 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9726231 | 0.74 | REN (0.55) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7433334 | 0.73 | METAP2 (0.42) | RENMETAP2METAP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |