SCHEMBL7430622

SCHEMBL7430622

Cc1ccc(CCC(CCCc2ccccc2)c2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.46
KCNH2 Q12809 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HRH1 P35367 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PLAAT3 P53816 1/20 0.41
PLAAT5 Q96KN8 1/20 0.41
PLAAT2 Q9NWW9 1/20 0.41
PLAAT4 Q9UL19 1/20 0.41
DRD3 P35462 2/20 0.41
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
F2 P00734 1/20 0.40
CNR2 P34972 1/20 0.40
SIGMAR1 Q99720 1/20 0.40
FDFT1 P37268 1/20 0.40
HTR2A P28223 1/20 0.40
CHRM2 P08172 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3015704 0.85 ALDH1A1 (0.45) CYP19A1ALDH1A1TDP1L3MBTL1SMN1; SMN2
SCHEMBL13814554 0.83 TP53 (0.47) CYP19A1KCNH2ALDH1A1TDP1L3MBTL1
SCHEMBL6546324 0.83 F2 (0.45) CYP19A1ALDH1A1HRH1TDP1L3MBTL1
SCHEMBL1538332 0.82 CYP19A1 (0.54) CYP19A1KCNH2ALDH1A1TDP1SMN1; SMN2
SCHEMBL28775673 0.81 SIGMAR1 (0.47) CYP19A1KCNH2DRD3SIGMAR1HTR2A
SCHEMBL28056319 0.81 CYP19A1 (0.49) CYP19A1KCNH2DRD3CNR2SIGMAR1
SCHEMBL3009093 0.81 ALDH1A1 (0.42) CYP19A1KCNH2ALDH1A1TDP1L3MBTL1
SCHEMBL6570932 0.80 CYP19A1 (0.46) CYP19A1KCNH2SIGMAR1FDFT1
SCHEMBL3020930 0.80 ALDH1A1 (0.41) CYP19A1KCNH2ALDH1A1TDP1L3MBTL1
SCHEMBL6547438 0.79 ALDH1A1 (0.44) CYP19A1ALDH1A1TDP1L3MBTL1F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1127049-A1 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL Holdings, Inc. (US) 2001-08-29 EP disclosed
EP-1085854-A1 N-LINKED SULFONAMIDE OF HETEROCYCLIC THIOESTER HAIR GROWTH COMPOUNDS AND USES GPI NIL Holdings, Inc. (US) 2001-03-28 EP disclosed
US-6121273-A ISOMERASE INHIBITORS EFFECTIVE AGAINST NEUROLOGICAL DISORDERS, I.E. PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS; SIDE EFFECT REDUCTION GPI NIL HOLDINGS, INC (US) 2000-09-19 US disclosed
WO-2000016603-A2 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL HOLDINGS, INC. (US) 2000-03-30 WO disclosed
US-6004993-A TREATMENT OF ALOPECIA IN ANIMALS GPI NIL HOLDINGS, INC. (US) 1999-12-21 US disclosed
WO-1999062489-A1 N-LINKED SULFONAMIDE OF HETEROCYCLIC THIOESTER HAIR GROWTH COMPOUNDS AND USES GPI NIL HOLDINGS, INC. (US) 1999-12-09 WO disclosed