Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621403 | 1.00 | FKBP1A (0.32) | FKBP1APREPPOLB | |
| SCHEMBL26968347 | 0.89 | POLB (0.37) | PREPPOLB | |
| SCHEMBL1526521 | 0.89 | POLB (0.37) | PREPPOLB | |
| SCHEMBL1526525 | 0.89 | POLB (0.37) | PREPPOLB | |
| SCHEMBL8578128 | 0.75 | MAOA (0.34) | POLB | |
| SCHEMBL1407014 | 0.74 | CA1 (0.39) | POLB | |
| SCHEMBL4559895 | 0.74 | CA1 (0.39) | POLB | |
| SCHEMBL10277056 | 0.74 | — | — | |
| SCHEMBL10602704 | 0.73 | POLB (0.33) | POLB | |
| SCHEMBL20660322 | 0.71 | CCR2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384238-B1 | ACYLATION OF STERICALLY HINDERED ALCOHOLS; METAL HALIDE CATALYST | LEK PHARMACEUTICAL AND CHEMICAL COMPANY D.D. (SI) | 2002-05-07 | — | — | US | claimed |
| CN-1215064-C | A process for producing simvastatin | CHEIL JEDANG CORP (KR) | 2005-08-17 | — | — | CN | disclosed |
| EP-1135380-A1 | PROCESS FOR THE PREPARATION OF SIMVASTATIN AND ANALOGS THEREOF | Lek Pharmaceutical and Chemical Co. D.D. (SI) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032585-A1 | PROCESS FOR THE PREPARATION OF SIMVASTATIN AND ANALOGS THEREOF | LEK PHARMACEUTICAL AND CHEMICAL COMPANY D.D. (DE) | 2000-06-08 | — | — | WO | disclosed |
| EP-0444888-B1 | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one | MERCK & CO INC (US) | 1995-02-08 | — | — | EP | disclosed |
| EP-0287340-B1 | NOVEL ACYLATION PROCESS FOR THE SYNTHESIS OF HMG-COA REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0325817-B1 | NOVEL HMG-COA REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0327166-B1 | NOVEL HMG-COA REDUCTASE INHIBITORS | Merck & Co., Inc. (US) | 1992-12-30 | — | — | EP | disclosed |
| EP-0320052-B1 | INTERMEDIATES AND PROCESSES FOR 6-CARBOXY HMG-COA REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1992-01-15 | — | — | EP | disclosed |
| EP-0444888-A1 | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one | MERCK & CO. INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| EP-0331240-A2 | Intermediates and processes for beta 6-hydroxymethyl HMG-COA | MERCK & CO. INC. (US) | 1989-09-06 | — | — | EP | disclosed |
| EP-0327166-A1 | Novel HMG-COA reductase inhibitors | MERCK & CO. INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| EP-0327165-A1 | HMG-COA reductase inhibitors | MERCK & CO. INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| EP-0283123-A2 | Intermediates and process useful in the preparation of HMG-COA reductase inhibitors | MERCK & CO. INC. (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4450171-A | 6-/8-ACYLOXY/POLYHYDRONAPHTH-1-YL/ETHYLENE/ TETRAHYDRO-2H-PYRAN-2- ONE | MERCK & CO., INC. (US) | 1984-05-22 | — | — | US | disclosed |