Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21056410 | 0.86 | ALDH1A1 (0.39) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL8424491 | 0.82 | — | — | |
| SCHEMBL3950972 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL235856 | 0.79 | — | — | |
| SCHEMBL3971866 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL13833159 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL154974 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL25214090 | 0.76 | ALOX15 (0.62) | ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL1100728 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL1097492 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200207779-A2 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Hongyun Biotech Co., Ltd. (CN) | 2020-07-02 | — | — | US | claimed |
| US-20190211030-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Hongyun Biotech Co., Ltd. (CN) | 2019-07-11 | — | — | US | claimed |
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | claimed |
| US-20090253638-A1 | Somatostatin Antagonists | BIOMEASURE, INCORPORATED | 2009-10-08 | — | — | US | claimed |
| EP-0956296-B1 | SOMATOSTATIN ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2006-06-21 | — | — | EP | claimed |
| US-20040097418-A1 | Somatostatin antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. | 2004-05-20 | — | — | US | claimed |
| EP-0956296-A2 | SOMATOSTATIN ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-11-17 | — | — | EP | claimed |
| WO-1998024807-A2 | SOMATOSTATIN ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A. (S.C.R.A.S.) (FR) | 1998-06-11 | — | — | WO | claimed |
| US-11078213-B2 | Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof | Hongyun Biotech Co., Ltd. (CN) | 2021-08-03 | — | — | US | disclosed |
| CN-107108686-B | RNA interference compositions and methods for malignancy | 日东电工株式会社 | 2021-07-16 | — | — | CN | disclosed |
| CN-109575045-B | Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof | 南京红云生物科技有限公司 | 2021-02-12 | — | — | CN | disclosed |
| US-20200207779-A2 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Hongyun Biotech Co., Ltd. (CN) | 2020-07-02 | — | — | US | disclosed |
| CN-104328100-B | The inhibition of neuroendocrine disease | 益普生生物创新有限公司 | 2019-08-23 | — | — | CN | disclosed |
| US-20190211030-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Hongyun Biotech Co., Ltd. (CN) | 2019-07-11 | — | — | US | disclosed |
| WO-1998024807-A2 | SOMATOSTATIN ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A. (S.C.R.A.S.) (FR) | 1998-06-11 | — | — | WO | disclosed |
| US-5523430-A | Protein farnesyl transferase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| US-5510510-A | Inhibitors of farnesyl protein transferase | BRISTOL-MEYERS SQUIBB COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0696593-A2 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-14 | — | — | EP | disclosed |
| EP-0675112-A1 | Imidazole-containing inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |
| EP-0618221-A2 | Heterocyclic inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253638-A1 | Somatostatin Antagonists | SSTR5, SSTR2, SSTR4 | ALDH1A1 4519/4885KDM4E 2789/4885KMT2A 2042/4885 |
| US-20040097418-A1 | Somatostatin antagonists | SSTR5, SSTR2, SSTR4 | ALDH1A1 4519/4885KDM4E 2789/4885KMT2A 2042/4885 |
| US-20190211030-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | ALK, MET, TIE1 | ALDH1A1 616/4885KDM4E 463/4885KMT2A 883/4885 |
| US-20200207779-A2 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | ALK, MET, TIE1 | ALDH1A1 616/4885KDM4E 463/4885KMT2A 883/4885 |
| US-11078213-B2 | Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof | ALK, MET, TIE1 | ALDH1A1 616/4885KDM4E 463/4885KMT2A 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.