Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796258 | 0.87 | GPR35 (0.55) | ERN1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL7430974 | 0.84 | FABP4 (0.58) | NPC1TP53RAB9AGAAFABP3 | |
| SCHEMBL7894667 | 0.79 | GAA (0.57) | KDM4EGAAHDAC4HDAC8POLB | |
| SCHEMBL27940845 | 0.75 | PARP1 (0.58) | NPC1TP53RAB9ASMN1; SMN2GPR35 | |
| SCHEMBL15782121 | 0.74 | KDM4E (0.53) | NPC1RAB9ASMN1; SMN2HSD17B1GPR35 | |
| SCHEMBL14585873 | 0.74 | ITGB1 (0.47) | TP53RAB9ASMN1; SMN2FABP3FABP4 | |
| SCHEMBL9357148 | 0.74 | JAK2 (0.56) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7333428 | 0.73 | ERN1 (0.44) | ERN1SMN1; SMN2GAAHDAC4HDAC8 | |
| SCHEMBL16712927 | 0.73 | HSD17B2 (0.60) | NPC1RAB9AHDAC4HDAC8POLB | |
| Benzene SCHEMBL28272579 | 0.73 | JAK2 (0.55) | NPC1TP53RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |