Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.58 |
| ▸ | FABP3 | P05413 | 1/20 | 0.58 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845535 | 0.86 | FABP4 (0.70) | FABP4FABP3FABP5NPC1HTT | |
| SCHEMBL7431016 | 0.84 | ERN1 (0.47) | FABP4FABP3FABP5NPC1RAB9A | |
| SCHEMBL7174236 | 0.83 | FABP4 (0.62) | FABP4FABP3FABP5NPC1CTSD | |
| SCHEMBL2362774 | 0.83 | FABP3 (0.58) | FABP4FABP3FABP5NPC1CTSD | |
| SCHEMBL14585873 | 0.82 | ITGB1 (0.47) | FABP4FABP3FABP5RAB9ATP53 | |
| SCHEMBL10718417 | 0.82 | ALDH1A1 (0.50) | FABP4FABP3FABP5HTTHPGD | |
| SCHEMBL14052868 | 0.81 | FABP4 (0.56) | FABP4FABP3FABP5NPC1CTSD | |
| SCHEMBL27512908 | 0.81 | FABP4 (0.56) | FABP4FABP3FABP5NPC1CTSD | |
| SCHEMBL8799869 | 0.81 | FABP3 (0.56) | FABP4FABP3FABP5NPC1HTT | |
| SCHEMBL431 | 0.80 | CTSD (0.63) | NPC1CTSDHTTRAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |