Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.41 |
| ▸ | PRP4K | Q13523 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442520 | 0.77 | CYP2A6 (0.58) | HTR6CA12CA1CA2CA9 | |
| SCHEMBL7431655 | 0.77 | S1PR4 (0.38) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7440332 | 0.72 | HTR6 (0.51) | HTR6KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6359855 | 0.71 | DYRK1A (0.51) | DYRK1ADYRK1BPRP4KKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7445772 | 0.71 | HTR6 (0.50) | HTR6KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL13707355 | 0.71 | CA12 (0.47) | HTR6CA12CA1CA2CA9 | |
| SCHEMBL30496750 | 0.71 | MTNR1A (0.58) | CA2MEN1MAPTKMT2AMTNR1A | |
| SCHEMBL4100261 | 0.71 | MTNR1A (0.58) | CA2MEN1MAPTKMT2AMTNR1A | |
| SCHEMBL7447300 | 0.69 | CYP1A2 (0.41) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL28128851 | 0.69 | MTNR1A (0.57) | CA2MEN1MAPTKMT2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397364-B1 | HETEROCYCLIC GUANIDINES AS 5HT 3 ANTAGONISTS | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0397364-A1 | Heterocyclic guanidines AS 5HT 3 Antagonists | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4963689-A | ANTIEMETICS, ANALGESICS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA | PFIZER INC. (US) | 1990-10-16 | — | — | US | disclosed |