Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431877 | 0.84 | KDM4E (0.39) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL3935379 | 0.81 | IP6K1 (0.52) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL31348132 | 0.81 | IP6K1 (0.52) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL17231387 | 0.81 | MEN1 (0.47) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL7436090 | 0.80 | PDE5A (0.38) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL4884359 | 0.79 | CBX7 (0.46) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL3931904 | 0.77 | CASP3 (0.54) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL9206539 | 0.75 | MEN1 (0.45) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL15341796 | 0.73 | OPRM1 (0.48) | MEN1KMT2AMAPTPDE4APDE4B | |
| SCHEMBL10381827 | 0.72 | PKM (0.51) | MEN1KMT2AMAPTPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933336-A | Thiadiazinone, oxadiazinone and triazinone derivatives, and their use for treating acute or chronic heart disease | LABORATOIRES SOBIO S.A. (FR) | 1990-06-12 | — | — | US | disclosed |
| EP-0303418-A2 | Substituted indolones, useful in the treatment of heart or asthmatic diseases | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1989-02-15 | — | — | EP | disclosed |