Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652648 | 0.84 | HTR1A (0.55) | MEN1KMT2AKDM4E | |
| SCHEMBL10498542 | 0.82 | LMNA (0.70) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL6663539 | 0.82 | — | — | |
| SCHEMBL2024052 | 0.81 | HTR1A (0.56) | — | |
| SCHEMBL9557902 | 0.80 | HTR1A (0.58) | ALDH1A1 | |
| SCHEMBL2633644 | 0.79 | MEN1 (0.54) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL6292618 | 0.78 | TMEM97 (0.51) | MEN1KMT2A | |
| SCHEMBL26492991 | 0.78 | HTR1A (0.65) | ALDH1A1 | |
| SCHEMBL26108581 | 0.78 | HTR1A (0.65) | ALDH1A1 | |
| SCHEMBL7297746 | 0.77 | POLB (0.59) | KDM4EMAPTALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012050884-A2 | CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-04-19 | — | — | WO | claimed |
| US-5580871-A | FOR TREATMENT OF CONGESTIVE HEART FAILURE | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-03 | — | — | US | claimed |
| EP-0475187-A1 | Naphthothiophenimines for treating neuronal disorders caused by ischemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-03-18 | — | — | EP | claimed |
| US-5064831-A | N-methyl-d-aspartate receptor antagonist | BRISTOL-MYERS SQUIBB CO. (US) | 1991-11-12 | — | — | US | claimed |
| US-20220054499-A1 | SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2022-02-24 | — | — | US | disclosed |
| US-11026952-B2 | Small molecules for mouse satellite cell proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-08 | — | — | US | disclosed |
| US-10660902-B2 | Method of increasing satellite cell proliferation with an HDAC inhibitor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3411040-A1 | SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION | President and Fellows of Harvard College (US) | 2018-12-12 | — | — | EP | disclosed |
| US-20180153902-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | HOWARD HUGHES MEDICAL INSTITUTE | 2018-06-07 | — | — | US | disclosed |
| WO-2017136480-A1 | SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-10 | — | — | WO | disclosed |
| EP-2646107-A2 | AGENT DELIVERY SYSTEMS FOR SELECTIVE NEUROMODULATION | Spinal Modulation Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012174537-A2 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012075337-A2 | DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY | SPINAL MODULATION, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012050884-A2 | CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-04-19 | — | — | WO | disclosed |
| US-5580871-A | FOR TREATMENT OF CONGESTIVE HEART FAILURE | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-03 | — | — | US | disclosed |
| US-5432188-A | Treating congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5215967-A | AMINOACID DERIVATIVES INHIBITING RENIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| US-5166147-A | Congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064831-A | N-methyl-d-aspartate receptor antagonist | BRISTOL-MYERS SQUIBB CO. (US) | 1991-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11026952-B2 | Small molecules for mouse satellite cell proliferation | MKI67, MYLK2, MYH2 | MEN1 4412/4885KMT2A 1908/4885KDM4E 1110/4885 |
| US-10660902-B2 | Method of increasing satellite cell proliferation with an HDAC inhibitor | HDAC4, HDAC1, HDAC5 | MEN1 4576/4885KMT2A 86/4885KDM4E 150/4885 |
| US-20220054499-A1 | SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION | MKI67, MYLK2, MYH2 | MEN1 4412/4885KMT2A 1908/4885KDM4E 1110/4885 |
| US-20180153902-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | MKI67, MYLK2, MYH2 | MEN1 4381/4885KMT2A 1776/4885KDM4E 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.