Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610124 | 0.87 | LMNA (0.61) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL2361740 | 0.83 | LMNA (0.60) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL6513577 | 0.83 | LMNA (1.00) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL8313 | 0.83 | LMNA (1.00) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL28527433 | 0.81 | LMNA (0.89) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL723791 | 0.81 | LMNA (0.96) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL1052095 | 0.81 | LMNA (0.96) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL7268962 | 0.81 | LMNA (0.96) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL15788918 | 0.81 | LMNA (0.96) | LMNACYP3A4MAPTKDM4ETSHR | |
| SCHEMBL7722989 | 0.81 | LMNA (0.96) | LMNACYP3A4MAPTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4973585-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | MERRELL DOW PHARMACEUTICALS (US) | 1990-11-27 | — | — | US | disclosed |
| EP-0326526-A1 | Aminoketones of substituted dibenzo- and pyridobenzo-azepinones and pharmaceutical compositions | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |
| EP-0326526-A1 | Aminoketones of substituted dibenzo- and pyridobenzo-azepinones and pharmaceutical compositions | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |
| EP-0288201-A1 | Process for the preparation of benzodiazepines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-10-26 | — | — | EP | disclosed |
| US-4749788-A | Process for the preparation of aryl-pyrido(1,4) benzodiazepines | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0249223-A2 | Novel antihypertensive agent | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-12-16 | — | — | EP | disclosed |