Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 2/20 | 0.48 |
| ▸ | SDCBP | O00560 | 1/20 | 0.47 |
| ▸ | SDC2 | P34741 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26644364 | 0.78 | PSMB5 (0.61) | MMP2PSMB5MME | |
| SCHEMBL7403300 | 0.78 | MMP1 (0.60) | MMP3MMP2PSMB5 | |
| SCHEMBL15692320 | 0.76 | PSMB5 (0.73) | MMP2PSMB5MME | |
| SCHEMBL10734396 | 0.76 | MME (0.63) | MMP2PSMB5MME | |
| SCHEMBL7402160 | 0.75 | MMP3 (0.60) | MMP3MMP2PSMB5 | |
| SCHEMBL6419209 | 0.75 | MMP3 (0.86) | MMP3MMP2 | |
| SCHEMBL7397757 | 0.75 | MMP3 (0.61) | MMP3MMP2PSMB5NPSR1 | |
| SCHEMBL9830825 | 0.74 | MME (0.66) | MMP3MMP2PSMB5MME | |
| SCHEMBL9830820 | 0.74 | MME (0.66) | MMP3MMP2PSMB5MME | |
| SCHEMBL7397714 | 0.74 | MMP1 (0.55) | MMP3MMP2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | claimed |
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |