Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.52 |
| ▸ | AKT1 | P31749 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | NEK4 | P51957 | 2/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.52 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672684 | 1.00 | RPS6KA5 (0.52) | RPS6KA5AKT1GSK3BNEK4PRKCD | |
| Hydrochloric Acid SCHEMBL11571121 | 0.98 | RPS6KA5 (0.51) | RPS6KA5AKT1GSK3BNEK4PRKCD | |
| SCHEMBL115980 | 0.85 | ROCK1 (0.55) | RPS6KA5AKT1GSK3BNEK4PRKCD | |
| SCHEMBL4598191 | 0.85 | ROCK1 (0.55) | RPS6KA5AKT1GSK3BNEK4PRKCD | |
| SCHEMBL7455436 | 0.84 | ADORA2A (0.49) | RPS6KB1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL186238 | 0.83 | LMNA (0.61) | KMT2ALMNASMN1; SMN2TACR3 | |
| Hydrochloric Acid SCHEMBL7973435 | 0.83 | RPS6KA5 (0.54) | RPS6KA5AKT1GSK3BNEK4PRKCD | |
| SCHEMBL186416 | 0.83 | LMNA (0.61) | KMT2ALMNASMN1; SMN2TACR3 | |
| SCHEMBL8582093 | 0.83 | RIPK1 (0.61) | RPS6KA5AKT1GSK3BNEK4PRKCD | |
| SCHEMBL607611 | 0.83 | RIPK1 (0.61) | RPS6KA5AKT1GSK3BNEK4PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4709032-A | VASODILATION AND HYPOTENSIVE AGENT | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-11-24 | — | — | US | disclosed |
| US-4634770-A | VASODILATORS, HYPOTENSIVES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-01-06 | — | — | US | disclosed |
| US-4560755-A | VASODILATOR, HYPOTENSOR | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-12-24 | — | — | US | disclosed |
| US-4525589-A | Isoquinolinesulfonyl derivatives | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-06-25 | — | — | US | disclosed |
| EP-0061673-B1 | ISOQUINOLINESULFONYL DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-24 | — | — | EP | disclosed |
| US-4456757-A | MUSCLE RELAXANTS, VASODILATORS, HYPOTENSIVE AGENTS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1984-06-26 | — | — | US | disclosed |
| EP-0109023-A1 | Isoquinolinesulfonamide derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-05-23 | — | — | EP | disclosed |
| EP-0061673-A1 | Isoquinolinesulfonyl derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-10-06 | — | — | EP | disclosed |