Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.58 |
| ▸ | MME | P08473 | 3/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424247 | 0.86 | ACE (0.61) | ACEMME | |
| SCHEMBL7422816 | 0.79 | SRC (0.49) | ACE | |
| SCHEMBL11104778 | 0.79 | LMNA (0.38) | ACE | |
| SCHEMBL11104772 | 0.79 | LMNA (0.38) | ACE | |
| SCHEMBL7330364 | 0.76 | ACE (0.55) | ACEMME | |
| SCHEMBL7330368 | 0.76 | ACE (0.55) | ACEMME | |
| SCHEMBL7433309 | 0.76 | ACE (0.36) | ACE | |
| SCHEMBL7426897 | 0.76 | ACE (0.41) | ACE | |
| SCHEMBL7433357 | 0.76 | ACE (0.81) | ACEMMEABCB11AGTR2PDE3A | |
| SCHEMBL10853559 | 0.76 | ACE (0.81) | ACEMMEABCB11AGTR2PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120728-A1 | Thiazine and thiazepine containing compounds | E.R. Squibb & Sons, Inc. (US) | 1984-10-03 | — | — | EP | disclosed |