Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14895438 | 0.89 | BRD4 (0.48) | BRD4ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7443835 | 0.84 | BRD4 (0.46) | BRD4HSP90AA1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7436030 | 0.81 | KDM4E (0.40) | ALDH1A1KDM4ECYP1A2LMNACYP3A4 | |
| SCHEMBL7439674 | 0.81 | IKBKB (0.39) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL28634780 | 0.81 | BRD4 (0.49) | BRD4ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL25347956 | 0.80 | BRD4 (0.48) | BRD4ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL15758316 | 0.80 | NUDT1 (0.51) | BRD4HSP90AA1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28550577 | 0.79 | BRD4 (0.47) | BRD4ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL27510506 | 0.78 | DPP4 (0.47) | BRD4ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7441626 | 0.75 | KDM4E (0.49) | BRD4ALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0656898-B1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5591742-A | TREATMENT OF ANGINA, HYPERTENSION, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0656898-A1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS. | PFIZER RES & DEV (IE) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994005661-A1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-03-17 | — | — | WO | disclosed |